Macs in Chemistry

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Installing Alphafold2 on Apple Silicon


AlphaFold2 is an artificial intelligence (AI) program developed by Alphabets's/Google's DeepMind which performs predictions of protein structure. Despite the name AlphaFold2 does not actually predict the folding mechanism instead it predicts the final 3D structure of a protein from the protein sequence DOI.

Source code for the AlphaFold model, trained weights and inference script are available under an open-source license at

I've compiled step by step instructions for installing Alphafold2 on a MacBook Pro M1 max here

Many thanks to Yoshitaka Moriwaki for help.