Calculating solvent accessible surface area is an important calculation in the study of protein structure and whilst there are many tools to undertake this sort of calculation FreeSASA represents the first open-source free standing tool for this sort of calculation. FreeSASA is an open source C library for SASA calculations that provides both command-line and Python interfaces.

Source code is available for download here and building the FreeSASA library and command-line interface only requires standard C and GNU libraries and a C99-compliant compiler, and should be straightforward on any UNIX system (has been tested in Mac OS X 10.8 and Debian 8).

Mitternacht S. FreeSASA: An open source C library for solvent accessible surface area calculations [version 1; referees: awaiting peer review]. F1000Research 2016, 5:189 DOI