The interactions of single molecules with nanopores are observed by measuring changes to the ionic current that occurs when the pore changes from an unoccupied (i.e., an open channel) to an occupied state. The electrical nature of the measurement allows us to model components of the physical system with equivalent electrical elements, and describe system behaviour collectively with the circuit response.

MOSAIC is a modular toolbox for analyzing data from single molecule experiments. Primarily developed to analyze data from nanopore experiments. MOSAIC’s GUI greatly simplifies analyzing data from single-molecule nanopore experiments and provides easy access to most common algorithms and data types. MOSAIC can also be scripted using PYTHON to run multiple analyses in batch mode. It can also be integrated into Mathematica, MATLAB or IGOR Pro workflows.

Balijepalli, A. Ettedgui, J, Cornio, A. T., Robertson, J. W. F. Cheung, K. P., Kasianowicz, J. J. & Vaz, C., ACS Nano 2014, 8, 1547–1553