Macs in Chemistry

Insanely Great Science



Foldit is a game in which players attempt to fold a protein sequence. Foldit players have a number of tools that allow them to change both the fold and the sequence of a virtual protein. The player's score is calculated from the energy of the virtual protein.

This work has now been published "De novo protein design by citizen scientists" DOI in Nature.

One hundred forty-six Foldit player designs with sequences unrelated to naturally occurring proteins were encoded in synthetic genes; 56 were found to be expressed and soluble in Escherichia coli, and to adopt stable monomeric folded structures in solution. The diversity of these structures is unprecedented in de novo protein design, representing 20 different folds—including a new fold not observed in natural proteins.

Download and instructions are here

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