I see a new version of ChemDraw has been released. The flyer suggests improved Mac support

ChemDraw 16 for Mac is 6x faster than previous versions and includes features such as: auto-save and versioning, an improved UI, Unicode support, Improved text rendering including for subscript characters and atom labels. What’s more, ChemDraw 16 for Mac offers improved multi-monitor and Retina (high DPI) display support.

Requirements are shown below, no mention of Mac OS X 10.12 (Sierra)

Following are the system requirements for the latest version of ChemDraw.

OS

• Mac OS X 10.10 (Yosemite)
• Mac OS X 10.11 (El Capitan)

RAM

• 32 bit OS: 1 GB
• 64 bit OS: 2 GB

Microsoft Office

• Microsoft Office 2011
• Microsoft Office 2016
• including Office 365 support

Initial comments suggest round-trip editing is now supported. No mention of Pages, Keynote, Open Office.