OpenEye have announced the release of OpenEye Toolkits v2017.Feb. These libraries include the usual support for C++, Python, C#, and Java.

EXAMPLE NEW FEATURES

FastROCS TK now allows customization of starting points for shape overlap optimization.
Quacpac TK now includes a flexible molecular charging engine.
OEMedchem TK now allows MCS similarity scores to be computed for a query molecule compared to a set of indexed target structures.