After being dormant for a while this project seems to have come back to life.

Mychem is a chemoinformatics extension for MySQL and MariaDB released under the GNU GPL license. It provides a set of functions that permits to handle chemical data within the database. These functions permit to search, analyze and convert chemical data. It is based on Open Babel.

A complete documentation for Mychem is available online and will give a good overview of its capabilities.

https://mychem.github.io/docs/

I'd be interested to hear if anyone has installed under Mac OSX.