Alvascience have just released an update to alvaMolecule https://www.alvascience.com/alvamolecule/.

Here is the list of the main changes of alvaMolecule:

• Import XYZ cartesian coordinates format (*.xyz)
• Export dataset as Excel file (*.xlsx)
• Delete molecules
• Find molecular structures in Google Patents/Scholar
• Molecule grid: filter molecules by substructure (SMARTS)
• Molecule grid: column value can be set as footer of a molecule cell
• Charts: added molecule hint on charts
• Charts: added context menu to save data of charts
• Charts: added 'Lasso selection'
• Highlight substructures (SMARTS)
• Highlight Bemis-Murcko features
• Standardizers: standardize nitro group as [N+]([O-](=O))
• Standardizers: remove radicals preserving usual valence
• Standardizers: neutralize atoms
• Standardizers: neutralize molecule
• Standardizers: custom standardizer with SMIRKS
• Checkers: modified the non-standard atom set which now includes the following atoms: H, B, C, N, O, P, S, F, Cl, Br, I
• Duplicate analysis: identify duplicated structures
• Duplicate analysis: automatically delete duplicated structures
• Duplicate analysis: identify molecules with the same value for a specific column
• Scaffold analysis: identify the Bemis-Murcko scaffolds

alvaMolecule is free for academic and non-commercial use.